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These receptors are coupled to inhibitory G-proteins (G i/o ), which inhibit adenylyl cyclase, deplete cyclic AMP (cAMP) levels, and suppress neuronal firing by opening potassium channels

doi: 10.1093/carcin/bgaa001 127 KlutznySAnurinANickeBReganJLLangeMSchulzeLet al

DNA damage-induced cell death by apoptosis
