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[Para 74] It appears that TNF-a decreases the availability of reduced glutathione, resulting in an increase in local oxidation stress, and at the same time sensitizes the membrane of the cell to increased damage from oxidation stress

A brief explanation is that a decline in the lipid peroxidation reaction due to attenuated Glu catabolism is a likely mechanism for the inhibition of ferroptosis in cells with a high capacity to produce -glutamyl peptides

, Kabwe L

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