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Additionally, chemical modification strategies (e.g., methylation, etherification, conjugation of BBB-targeting groups) or targeted synthesis based on BBB penetration principles can optimise physicochemical properties (e.g., reducing water solubility, enhancing lipophilicity to match the BBBs lipid bilayer characteristics) or evade recognition by BBB efflux transporters, thereby significantly improving target drug penetration efficiency (Narsinh et al., 2024)

[VERIFY: confirm GHK-Cu plasma level decline figures with published source before publishing] BPC-157 repairs the specific area that is damaged