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These immune stimulatory factors function as damage-associated molecular patterns, which can transcriptionally activate pro-inflammatory cytokines (TNF-, IL-1, IL-6 and IL-10) and chemokines (MCP-1, MIP-2 and IL-8) [25], [51], [68]

When consumed in excess, it is known that some folic acid is converted into reduced folates within the intestinal cell, but some is absorbed intact and enters the portal circulation as UMFA (67)

Since tissue repair occurs predominantly during these deep sleep stages, improved rest directly translates to accelerated recovery outcomes

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