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The seven methods were performed using the R package ( was illustrated in Supplementary Figure 1

In cases of CKD, elevated serum levels of IS contribute to AD development by disrupting the BBB and impairing cognitive functions (Salminen, 2023)
Hair follicles become less active, leading to weaker strands and more hair shedding
The Role of Vitamin B12 Vitamin B12 plays a crucial role in energy production, red blood cell formation, and maintaining a healthy nervous system