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Description
Microglia-derived HIV Nef+ exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides
Dose: Every hour until symptoms start to improve
doi: 10.1016/j.bbrc.2019.10.006 131 HansonLRRoeytenbergAMartinezPMCoppesVGSweetDCRaoRJet al
Many peptide- and protein-based drugs are pH-sensitive and prone to hydrolysis, deamidation, or oxidation outside their optimal pH range, which can compromise therapeutic efficacy (Illum, 2003
