chloroquine glutathione synthase Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells Glutathione synthetase deficiency | MedLink
Description
Protein thiol homeostasis: Glutathione maintains proteins in their reduced (functional) state through S-glutathionylation, a reversible post-translational modification that regulates protein activity under oxidative stress [2]
However, the inherited defective glutathione synthetase blocks or slows the conversion of -glutamylcysteine to glutathione
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As B12 deficiency progresses, it can also impact your nervous system, leading to neurological symptoms
