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It remains to be clarified whether eosinophil plasticity or heterogeneity underlies the apparent ability of these cells to contribute to mucosal tissue homeostasis during the steady state, versus their proposed pathological role in disease states such as asthma, EoE 1 , and colitis

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Status of clinical trials involving anti-IGFs and IGF-1R mAbs The preclinical findings that support IGF-1 and its receptor IGF-1R as potential therapeutic targets led to the initiation of many clinical trials in the last decade (Table 1)