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CNF toxin binds to the tight junctions of colonic epithelial cells which internalize it by endocytosis and promotes cell proliferation by encouraging entry into the cell cycle and the G1/S transition for cell survival by inducing, in particular, the expression of the anti-apoptotic proteins Bcl-2 (B-cell lymphoma 2) and Bcl-xl (B-cell lymphoma-extra-large) [154]

Antagonist at adenosine receptor subtype A1

However, excessive intake may lead to side effects such as gastrointestinal discomfort and potential cardiovascular risks

Conclusion This is the first MR analysis to investigate the causality of CSF and blood metabolites in NMOSD