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Description
Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH mutant cells to alkylating agents
Additionally, double-stranded RNA-activated protein kinase (PKR) has been identified as a key transducer of inflammatory signals in colonic epithelial cells
30 On the other hand, restoring sleep health is an important part of treatment for mental health disorders through its ability to regulate stress signaling, reduce brain inflammation, and improve neuroplasticity

(2) Increased substrate accessibility, and (3) inflexibility in metabolism changes
