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It also modifies histones, thereby disrupting chromatin structure and generating genotoxic histoneDNA crosslinks [116]

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No significant differences were observed with respect to the percentage of lung lesions when the entire study population of cohort 2 was analyzed

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However, it also highlights a therapeutic opportunity: overwhelming this protective system with high, localized doses delivered via NO-releasing nanocarriers can trigger ferroptotic cell death in CRC cells (Table 3)

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doi: 10.1128/aem.62.11.4238-4242 [DOI] [PMC free article] [PubMed] [Google Scholar] 55

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