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However, Li et al reported that insulin-mediated up-regulation of GSH synthesis in cardiac myocytes required PI3K, MEK and p38 MAPK (Li et al., 2003)

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Collectively, this body of work have demonstrated that CAP's effectiveness against nociceptive pain is grounded in specific, interacting mechanisms, ranging from molecular antiinflammatory and proregenerative actions to physical modulation of skin permeability, which collectively resolve the tissue pathology responsible for pain generation

Clinical development of therapies targeting TGF: current knowledge and future perspectives