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Most of the proteins have features related to the cytosolic subfamily, two have features of the kappa subfamily and one has features of the microsomal subfamily
doi: 10.1038/nature01680
But many times, theyre triggered by outside sources like: Sun exposure (UV radiation) Air pollution Cigarette smoke Toxins and chemicals Stress and poor diet An overload of free radicals sets off something called oxidative stress
Ann Allergy Asthma Immunol 2007;99(1):82-6 2) Cox L, Larenas-Linnemann D, Lockey RF, et al
