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Interestingly, a specific GPX1 polymorphism resulting in a proline-to-leucine transition at position 198 (Pro198Leu) is associated with a reduction in GPx1 activity and found to be more prevalent in Keshan patients

Dhouib IE, Jallouli M, Annabi A, Gharbi N, Elfazaa S, Lasram MM (2016) A minireview on N -acetylcysteine: an old drug with new approaches

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