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The end result is a higher risk of damage due to oxidative stress, chronic inflammation, and diseases that are associated with both, including COVID-19 and comorbidities that increase risk of severity and death due to COVID-19
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It should be pointed out that the expression of Nrf2 target genes differs between neurons and glial cells (especially astrocytes), with glial cells predominating
Immunostaining for PCNA also showed that treatment with insulin and IGF-1 increased PCNA positive cell numbers in the cultured metatarsal bone sections (Figure 1e and 1f)
