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These factors include potent inflammatory regulators such as Interleukin (IL)-6, Leukemia inhibitory factor (LIF), C-X-C motif chemokine ligand (CXCL)1, CC motif chemokine ligand (CCL)5, and Colony stimulating factor (CSF) 1 [168]

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They come primarily from industry-sponsored cosmetic studies rather than large, independent, placebo-controlled dermatological trials