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Copper deficiency can cause a similar picture, including sensory ataxia and myelopathy (spinal cord involvement), and should always be considered alongside B12 deficiency
While this may provide localized antioxidant support, glutathione is a large molecule that does not easily penetrate the deeper layers of the skin where melanin is produced

This phenotype was absent from the catalase/peroxidase-proficient parent, showing that it depends upon H 2 O 2 stress (Figure 8C)
