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10 nM FITC-labeled sCT(2232) was used as the peptide probe for CTR ECD binding, while 10 nM FITC-labeled AC413(6-25) with Y25P mutation was used as the peptide probe for all RAMP ECD-CTR ECD fusion proteins
As a factor affecting this balance, IGF-1 signaling is essential for the survival and proliferation of many normal and malignant cell types and protects these cells from programmed cell death [47,48]
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