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Brain In the transient mouse middle cerebral artery occlusion (MCAO) model, liproxstatin-1 treatment commencing at the time of early reperfusion markedly attenuated MCAO-induced functional deficits, improved the neuroscore and reduced infarct volumes, suggesting a direct involvement of ferroptosis in ischemic stroke [502]

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Factors involved in the Th1 reaction, including tumour necrosis factor- (TNF-), recombinant human interferon- (IFN-), interleukin (IL)-12, and IL-18, have been proven to promote atherosclerosis through leukocyte recruitment, EC injury, and oxidative stress (3236)