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This enzyme complex is composed of the E1 component protein encoded by the DHTKD1 (dehydrogenase E1 and transketolase domain containing 1) gene and shares the E2 (dihydrolipoamide S-succinyltransferase: DLST) and E3 (dihydrolipoamide dehydrogenase: DLD) components of the 2-oxoglutarate complex of the TCA cycle (commonly called -ketoglutarate dehydrogenase)

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