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Shrimp JH, Hu J, Dong M, Wang BS, MacDonald R, Jiang H, et al

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The body's capacity to absorb B12 from food is naturally limited by intrinsic factor, a protein produced in the stomach that binds to B12 and facilitates its absorption in the small intestine

The goal of the 3R Principle is to avoid animal experiments altogether (Replacement) and to limit the number of animals (Reduction) and their suffering (Refinement) in tests to an absolute minimum