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Consistent with the observation that GSNO in a great excess of CoA reduces PDHC inhibition, we also found that although a low concentration of SNO-CoA in the presence of NADH can cause substantial inhibition of PDHC, adding a larger amount of the NO donor PAPA NONOate on top made the overall inhibition weaker (Fig

In addition, accumulated homocysteine in hepatic cells causes endoplasmic reticulum stress and disturbs the sterol response pathway, leading to NAFLD progression 22

10.1111/bph.15702 132 LuX.LvC.ZhaoY.WangY.LiY.JiC.et al (2022)