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Statins are recommended as first drug of choice, whereas omega-3 fatty acids, particularly high-dose icosapent ethyl (EPA), have shown significant CV risk reduction in patients with persistent hypertriglyceridemia despite statin therapy

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Eur J Gastroenterol Hepatol 28:12801284 Evans AM, Fornasini G (2003) Pharmacokinetics of L-carnitine

But not all people with hypothyroidism thrive on levothyroxine alone
