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High-protein diet effects on appetite and gut peptides

Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)

Jrvinen, A., Laine, M

Collectively, these findings indicate that HDAC9 is dynamically regulated during aging and in the context of AD pathology