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20 Similarly, in a study by Kawai et al of 75 patients with CCS receiving cisplatin-based chemotherapy regimens, the objective tumor response was low (23%)

and stage IVb, an advanced local disease involving the brain, dura, skull base, lower cranial nerves, and masticatory space [46,47] Proper imaging, including MRI and PET/CT scans, is crucial for assessing the anatomical relationships between healthy tissues and the neoplasm

It has been suggested that hydrophobic surfaces lead to a more open conformation of CalB giving easier access to the substrate [57]

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