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This means that the clinical effectiveness of GSHand that of its precursors like NACis dependent not only on its capability to act as an antioxidant, but also the degree to which their pharmacodynamic properties are in line with the dysfunction in cellular signaling, redox imbalance, and immune response generated by specific disease states (Fraternale et al., 2021)

Reactive Oxygen Species and Antioxidants Tumor cells can only survive within a narrow window of ROS levels

10.1042/BJ20101867 Veret J, Coant N, Berdyshev EV, Skobeleva A, Therville N, Bailb D, Gorshkova I, Natarajan V, Portha B, Le Stunff H: Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 -cells

Rev 44 (2015) 80978123