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[DOI] [PMC free article] [PubMed] [Google Scholar] 205.Hillbom M, Pieninkeroinen I, Leone M

Upon the release of zonulin into the lumen as a result of intestinal exposure to gliadin, zonulin can interact with two receptors, epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2), which results in increased intestinal permeability (27, 32)

J Biol Chem 276 : 43894397

184 NAD + manipulates the gene expression Cellular metabolism, such as NAD + metabolism, is directly connected to gene expression through regulating the post-translational modifications (PTMs) of histones, the covalent chemical modifications of DNA, the activity of transcription factor and RNA processing