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As is the case with occludin, some claudin isoforms are phosphorylated in the cells,30 and this phosphorylation is associated with localization and paracellular permeability

The presence of insulin resistance and elevated pro-inflammatory cytokines (e.g., tumor necrosis factor-) induce hepatic GH resistance (64), causing increases in GH and decreases in IGF-I levels ( Table 1 )
