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Y1135 (being the first tyrosine to be phosphorylated after stimulation with ligand) in the a-loop is bound in cis position in the active site, thus preventing the substrate access and occluding the ATP binding site as well
We are conveniently located at 12932 N
Immunology Letters,NagaseM.ShiotaT.TsushimaA.MurshedulM.FukuokaS.YoshizawaT.SakatoN.2002 156
In some cases, however, dry mouth may indicate an underlying condition: Diabetes, salivary gland disorders, HIV, and other diseases may cause a dry mouth
