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These include nausea and vomiting, auditory disturbances, headache, tactile disturbances, paroxysmal sweats, agitation, tremor, visual disturbances, orientation and clouding of sensorium, and anxiety

Furthermore, clinical manifestations of withdrawal, such as dysphoria and irritability, mirror neurobiological adaptive mechanisms that involve greater stress sensitivity and hyperactivation of the hypothalamic-pituitary-adrenal axis, which could account for the increase in BDNF levels [38, 39]