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2,15,18 Lactic acidosis is a manifestation of poor tissue perfusion and can be aggravated by inhibition of mitochondrial calcium entry leading to decreased pyruvate dehydrogenase activity.18,19 Other effects are bowel infarction and ileus.2,20-22 Pulmonary oedema23-26 (both cardiogenic and non-cardiogenic) might be caused by excessive fluid resuscitation and precapillary vasodilatation, resulting in increased transcapillary pressure

Both vitamin D synthesis and tryptophan metabolism are affected by UV exposure, and reduced UV exposure may impair mucosal immunity and induce changes in the gut microbiome 59

L-arginine supplementation can lower blood pressure and should be used cautiously in individuals taking antihypertensive medications or those with existing hypotension

A study involving the use of vitamin E in combination with vitamin C and beta carotene showed significantly reduced DNA damage in cats with renal insufficiency