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This requirement has been in effect since October 23, 2009, under the Enforcement Rule of the Narcotics Control Act

LL6, the most promising novel small molecule kinase inhibitor obtained, induced apoptosis and suppressed the colony-forming capacities of various drug-resistant NSCLC cell lines, suppressed NSCLC cell migration, suppressed NSCLC xenograft tumor growth and Lewis lung carcinoma allograft tumor metastasis in mice, and markedly reduced the number and burden of lung tumors in KrasG12D/+ transgenic mice, with low toxicity (54)

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This highlights the need for further research to better understand ZEN metabolism and excretion in humans