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NSAIDs also have harmful effects on the liver, kidneys, GI tract and cardiovascular system, while steroids can affect blood sugar levels and cause weight gain, exacerbating metabolic issues that contribute to knee OA

This regulatory function occurs via macrophage polarization in response to both internal and external environmental or pathological stimuli (Ying et al

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In cases of low product yield, Western blotting can be used to detect the expressed protein
