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tuberculosis invasion, macrophages deploy a repertoire of defense strategies, including phagosome-lysosome fusion to degrade pathogens, recruitment of hydrolytic lysosomal enzymes, production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), antigen presentation, upregulation and mobilization of major histocompatibility complex class II (MHC class II) molecules, autophagy, and induction of apoptosis (36)

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