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however, in the initial stage of atherosclerosis, turbulent blood flow interrupts these connections, making them more permeable, or leaky, and allowing lipoproteins to penetrate into the space under the endothelial cells, known as the intima

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Introduction Hydroxymethyl glutaryl coenzyme A reductase (HMG-CoA) inhibitors, commonly known as statins, work by competitively inhibiting HMG-CoA reductase, the rate limiting enzyme of the cholesterol synthetic pathway