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Of the 30 enrolled participants, 26 completed the required study phases and were included in the final analysis

HIF-1 up-regulates the expression of Glutaminase (GLS) to promote the decomposition of glutamine into glutamate, which is further converted to -ketoglutarate (-KG), which enters the tricarboxylic acid cycle (TCA cycle) to support energy production ( Metabolic adaptations induced by ID aid in tumor cell survival and drive their progression

The pathogenesis of IPF involves multiple pathological processes, including DNA damage, transforming growth factor beta (TGF-) signaling transduction, oxidative stress, inflammatory stimulation, and ECM deposition [18]