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For example, uricasePEG conjugates diminish immunogenicity and extend half-life

Cardiovascular outcomes with ertugliflozin in type 2 diabetes

Clinical observations revealed that chemotherapy could result in adverse events, including cardiotoxicity, organ damage, and myelosuppression which also represent major obstacles to the reversal of drug resistance through the application of small molecules to block MDR genes (395, 396)

However, clinical human trials are still limited
