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The functional role of the nonoxidative phase of the pathway is to regenerateG-6-P for the oxidative phase by shuffling carbon skeletons, interconverting 3-, 4-, 5-, 6- and 7-carbon sugars, through the action of the enzymes transaldolase (catalyzes the transfer of 3C) and transketolase (which catalyzes the transfer of 2C) (see Figure 2)

Low glutathione levels are found in people with lupus, rheumatoid arthritis (RA), Crohns disease (IBD), multiple sclerosis (MS), and psoriasis.[ref] Related articles: Lupus, Rheumatoid arthritis, IBD, MS, and psoriasis genes Cystic fibrosis: People with cystic fibrosis, which is a genetic disease caused by mutations in the CFTR gene, have frequent respiratory infections that cause lung inflammation and produce oxidative stress in the lungs, which depletes glutathione levels