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They are blocking one output of a much larger process
Possible side effects may include: Acne breakouts Headaches Nausea Dizziness Skin flushing Digestive discomfort In rare situations, extremely high B12 levels may also indicate underlying health conditions rather than supplement use itself
Running TB-500 continuously, back to back with no break, isn't something the data supports one way or the other, so the break is the safer default
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