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Also, treatment with busulfan as a cytotoxic agent can cause abnormal apoptosis in spermatogonial cell lines, leading to a pathological condition

Serum metabolomics predicted on average 25% of eGFR variance after 100 iterations

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However, one should bear in mind that duloxetine has previously been identified, in pre-marketing clinical trials and post-marketing monitoring, as a causative agent of liver injury (DeSanty and Amabile 2007) and thereby it had not been prescribed to patients believed to present higher susceptibility to DILI (e.g., elderly, obese patients, individuals with diabetes, chronic renal failure, etc.)