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During ischemia, reduced oxygen supply impairs ATP production, disrupts cellular integrity, and causes ionic imbalances, leading to cellular damage

Letourneau et al., 2021) Endothelial XO expression is increased in response to proatherosclerotic stimuli such as angiotensin II (Ang II) treatment and oscillatory shear stress (Bartekova et al., 2019

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Discrepancies in these fine-tuned microbiota interactions during each developmental stage can have long-term effects on disease susceptibility, such as metabolic syndrome, childhood asthma, or autoimmune type 1 diabetes
