local glutathione reperfusion Frontiers Different types of cell death

Interestingly, tumours in mice fed with high glutamine diet were much more sensitive to PLX4032 treatment indicating that combining these interventions could improve therapeutic response (Fig

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doi: 10.1089/ars.2012.5027

Prolonged ER stress and activation of the unfolded protein response (UPR) contribute to macrophage apoptosis as substantiated by studies showing that apoptosis and the UPR effector, CHOP, increase with each stage of atherosclerosis in humans, but the largest increase is observed in the vulnerable plaque (175)