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Description
Prolonged low oxygen levels ensure the stability of the transcription factor hypoxia-inducible factor-1 (HIF-1), which promotes the pro-inflammatory character of activated microglia and increases the production of cytokines such as IL-1, IL-6, and TNF- [24, 53]

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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