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In brain-targeted delivery, DTR can serve as a potential target for delivering drugs or therapeutic molecules to specific brain cells by conjugating them with DT or its derivatives [74]

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The combination of HIF-1 inhibitor PX-478 and immune checkpoint blockade has shown good anti-tumor effects, reducing EMT and enhancing treatment response (185, 186)

To clarify brain tissue samples, they were fixed with 4% PFA at 4 C for 24 h and then treated with Quadrol destaining solution at 37 C for 2 days