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Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of -aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum

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Supporting phase II detox of the 2-OH and 4-OH metabolites The 2-OH and 4-OH estrogen metabolites are cleared out in phase II primarily through methylation , which is carried out by the catechol-o-methyltransferase (COMT) enzyme