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However, owing to their limited anticancer activity or drug toxicity, a number of clinical trials targeting IGF-1R have been abandoned and few drugs have actually entered clinical use

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Molecular and Cellular Biochemistry 124 (2):149-158 Margarido TCS, Felicio AA, Rossa-Feres DC, Almeida EA (2013) Biochemical biomarkers in Scinax fuscovarius tadpoles exposed to a commercial formulation of the pesticide fipronil
