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They also showed that the activation of p53, via p21, inhibits cell activity and leads to cell cycle arrest with premature senescence of ECs progenitors [101]

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250 The tumor microenvironment may be one of the culprits for therapeutic resistance, and researchers have found that maintaining or inhibiting the expression of certain molecules in the tumor microenvironment is a pathway for overcoming drug resistance

Following conjugation, GSH-conjugated metabolites are exported via multidrug resistance-associated proteins (MRPs) and processed through the mercapturic acid pathway for renal excretion