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However, due to the toxicity of mitochondrial inhibitors and the absence of experimental animal models, our understanding of the contribution of excessive mitochondrial ROS to in vivo disease is limited
Glutathione S-transferase M1 (GSTM1) is another important metabolic enzyme gene that catalyzes the conjugation of glutathione with electrophilic compounds, converting activated carcinogens into inactive, water-soluble substances for excretion
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