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During the resolution of inflammation, SPMs produced by polymorphonuclear cells and macrophages act to limit local tissue damage caused by inflammatory responses, including signaling cessation of polymorphonuclear cell infiltration, macrophage switching to an anti-inflammatory phenotype, apoptotic cell clearance, and reducing pain caused by nociceptor sensitization (49, 61)

They found that Retatrutide reduces the levels of a protein complex called ANGPTL3/8, which is known to increase fats like triglycerides and LDL cholesterol

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