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In fact, strategies aimed at buffering microenvironment pH before administration of standard chemotherapy have been proposed by both preclinical 42 and clinical studies [Clinical trials NCT01198821] 43
Shepard Specialty Papers, Watertown, TN) in a climate and temperature-controlled room (72 2 F) on a 12 hr/12 hr light/dark cycle (lights on at 13:15)
He speculates that exposures to porphyrogenic chemicals, medications or severe infection, overpower the already deficient enzyme system resulting in accumulation of the specific porphyrin because of diminished enzyme function
Cancer 127(19):3541-3551, 2021
